The CHOICE trial: adalimumab demonstrates safety, fistula healing, improved quality of life and increased work productivity in patients with Crohn's disease who failed prior infliximab therapy.

Certolizumab pegol in patients with moderate to severe Crohn's disease and secondary failure to infliximab.

What do we need to know prior to thinking about incorporating an epigenetic evaluation into safety assessments?

Arsenate and dimethylarsinic acid in drinking water did not affect DNA damage repair in urinary bladder transitional cells or micronuclei in bone marrow.

Mycophenolate mofetil for autoimmune hepatitis: a single practice experience.

A data-based assessment of alternative strategies for identification of potential human cancer hazards.

Potential for a global historical control database for proliferative rodent lesions.

Best practices for use of historical control data of proliferative rodent lesions.

Surgical dilemma: liver resection or liver transplantation for hepatocellular carcinoma and cirrhosis. Intention-to-treat analysis in patients within and outwith Milan criteria.

An unusual presentation of eosinophilic esophagitis.

Dimethylarsinic acid in drinking water changed the morphology of urinary bladder but not the expression of DNA repair genes of bladder transitional epithelium in F344 rats.

Thyroid histopathology assessments for the amphibian metamorphosis assay to detect thyroid-active substances.

Finfish and aquatic invertebrate pathology resources for now and the future.

Coordinated changes in xenobiotic metabolizing enzyme gene expression in aging male rats.

Gene profiling in the livers of wild-type and PPARalpha-null mice exposed to perfluorooctanoic acid.