A Fragment-Based Method of Creating Small-Molecule Libraries to Target the Aggregation of Intrinsically Disordered Proteins.

Joshi P, Chia S, Habchi J, Knowles TP, Dobson CM, Vendruscolo M

An Environmentally Sensitive Fluorescent Dye as a Multidimensional Probe of Amyloid Formation.

Yates EV, Meisl G, Knowles TP, Dobson CM

Lymph-Node Palpation--No Laughing Matter.

Dobson CM, Stringfellow EA, Banks ME

Kinetic model of the aggregation of alpha-synuclein provides insights into prion-like spreading.

Iljina M, Garcia GA, Horrocks MH, Tosatto L, Choi ML, Ganzinger KA, Abramov AY, Gandhi S, Wood NW, Cremades N, Dobson CM, Knowles TP, Klenerman D

Alpha-Synuclein Oligomers Interact with Metal Ions to Induce Oxidative Stress and Neuronal Death in Parkinson's Disease.

Deas E, Cremades N, Angelova PR, Ludtmann MH, Yao Z, Chen S, Horrocks MH, Banushi B, Little D, Devine MJ, Gissen P, Klenerman D, Dobson CM, Wood NW, Gandhi S, Abramov AY

An anticancer drug suppresses the primary nucleation reaction that initiates the production of the toxic Aβ42 aggregates linked with Alzheimer's disease.

Habchi J, Arosio P, Perni M, Costa AR, Yagi-Utsumi M, Joshi P, Chia S, Cohen SI, MĂźller MB, Linse S, Nollen EA, Dobson CM, Knowles TP, Vendruscolo M

Automated Ex Situ Assays of Amyloid Formation on a Microfluidic Platform.

Saar KL, Yates EV, MĂźller T, Saunier S, Dobson CM, Knowles TPJ

Molecular mechanisms of protein aggregation from global fitting of kinetic models.

Meisl G, Kirkegaard JB, Arosio P, Michaels TC, Vendruscolo M, Dobson CM, Linse S, Knowles TP

Chaperome screening leads to identification of Grp94/Gp96 and FKBP4/52 as modulators of the Îą-synuclein-elicited immune response.

Labrador-Garrido A, Cejudo-GuillĂŠn M, Daturpalli S, Leal MM, Klippstein R, De Genst EJ, Villadiego J, Toledo-Aral JJ, Dobson CM, Jackson SE, Pozo D, Roodveldt C

Microfluidic Diffusion Analysis of the Sizes and Interactions of Proteins under Native Solution Conditions.

Arosio P, MĂźller T, Rajah L, Yates EV, Aprile FA, Zhang Y, Cohen SI, White DA, Herling TW, De Genst EJ, Linse S, Vendruscolo M, Dobson CM, Knowles TP

Hamiltonian Dynamics of Protein Filament Formation.

Michaels TC, Cohen SI, Vendruscolo M, Dobson CM, Knowles TP

Solvent exposure of Tyr10 as a probe of structural differences between monomeric and aggregated forms of the amyloid-β peptide.

Aran Terol P, Kumita JR, Hook SC, Dobson CM, EsbjĂśrner EK

Structure-Free Validation of Residual Dipolar Coupling and Paramagnetic Relaxation Enhancement Measurements of Disordered Proteins.

Newby FN, De Simone A, Yagi-Utsumi M, Salvatella X, Dobson CM, Vendruscolo M

Single-molecule FRET studies on alpha-synuclein oligomerization of Parkinson's disease genetically related mutants.

Tosatto L, Horrocks MH, Dear AJ, Knowles TP, Dalla Serra M, Cremades N, Dobson CM, Klenerman D

SOD1 protein aggregates stimulate macropinocytosis in neurons to facilitate their propagation.

Zeineddine R, Pundavela JF, Corcoran L, Stewart EM, Do-Ha D, Bax M, Guillemin G, Vine KL, Hatters DM, Ecroyd H, Dobson CM, Turner BJ, Ooi L, Wilson MR, Cashman NR, Yerbury JJ