Supersaturated proteins are enriched at synapses and underlie cell and tissue vulnerability in Alzheimer's disease.

Nature and Regulation of Protein Folding on the Ribosome.

Bacterial production and direct functional screening of expanded molecular libraries for discovering inhibitors of protein aggregation.

Using Tetracysteine-Tagged TDP-43 with a Biarsenical Dye To Monitor Real-Time Trafficking in a Cell Model of Amyotrophic Lateral Sclerosis.

Probing the dynamic stalk region of the ribosome using solution NMR.

Enhancement of the Anti-Aggregation Activity of a Molecular Chaperone Using a Rationally Designed Post-Translational Modification.

An engineered monomer binding-protein for Îą-synuclein efficiently inhibits the proliferation of amyloid fibrils.

Differential Interactome and Innate Immune Response Activation of Two Structurally Distinct Misfolded Protein Oligomers.

Determination of the structural ensemble of the molten globule state of a protein by computer simulations.

Fast Fluorescence Lifetime Imaging Reveals the Aggregation Processes of Îą-Synuclein and Polyglutamine in Aging Caenorhabditis elegans.

The Toxicity of Misfolded Protein Oligomers Is Independent of Their Secondary Structure.

Defining Îą-synuclein species responsible for Parkinson's disease phenotypes in mice.

The metastability of the proteome of spinal motor neurons underlies their selective vulnerability in ALS.

Probing the Origin of the Toxicity of Oligomeric Aggregates of Îą-Synuclein with Antibodies.

Biophysical Techniques in Structural Biology.