Unsupervised Deep Learning of Electronic Health Records to Characterize Heterogeneity Across Alzheimer Disease and Related Dementias: Cross-Sectional Study.

West M, Cheng Y, He Y, Leng Y, Magdamo C, Hyman BT, Dickson JR, Serrano-Pozo A, Blacker D, Das S

CASP8 intronic expansion identified by poly-glycine-arginine pathology increases Alzheimer's disease risk.

Nguyen L, Ajredini R, Guo S, Romano LEL, Tomas RF, Bell LR, Ranum PT, Zu T, BaĂąez Coronel M, Kelley CP, Redding-Ochoa J, Nizamis E, Melloni A, Connors TR, Gaona A, Thangaraju K, Pletnikova O, Clark HB, Davidson BL, Yachnis AT, Golde TE, Lou X, Wang ET, Renton AE, Goate A, Valdmanis PN, Prokop S, Troncoso JC, Hyman BT, Ranum LPW

Amyloid-β predominant Alzheimer's disease neuropathologic change.

Kovacs GG, Katsumata Y, Wu X, Aung KZ, Fardo DW, Forrest SL, Alzheimer's Disease Genetics Consortium, Nelson PT

Astrocyte transcriptomic changes along the spatiotemporal progression of Alzheimer's disease.

Serrano-Pozo A, Li H, Li Z, MuĂąoz-Castro C, Jaisa-Aad M, Healey MA, Welikovitch LA, Jayakumar R, Bryant AG, Noori A, Connors TR, Hu M, Zhao K, Liao F, Lin G, Pastika T, Tamm J, Abdourahman A, Kwon T, Bennett RE, Woodbury ME, Wachter A, Talanian RV, Biber K, Karran EH, Hyman BT, Das S

TYK2 regulates tau levels, phosphorylation and aggregation in a tauopathy mouse model.

Kim J, Tadros B, Liang YH, Kim Y, Lasagna-Reeves C, Sonn JY, Chung DC, Hyman B, Holtzman DM, Zoghbi HY

A cross-disease resource of living human microglia identifies disease-enriched subsets and tool compounds recapitulating microglial states.

Tuddenham JF, Taga M, Haage V, Marshe VS, Roostaei T, White C, Lee AJ, Fujita M, Khairallah A, Zhang Y, Green G, Hyman B, Frosch M, Hopp S, Beach TG, Serrano GE, Corboy J, Habib N, Klein HU, Soni RK, Teich AF, Hickman RA, Alcalay RN, Shneider N, Schneider J, Sims PA, Bennett DA, Olah M, Menon V, De Jager PL

Potential impact of the COVID-19 pandemic on everyday preferences for persons with cognitive impairment.

Wilkins JM, Locascio JJ, Gomez-Isla T, Hyman BT, Blacker D, Forester BP, Okereke OI

Differential regulation of brain microvessel transcriptome and brain metabolome by western and heart-healthy dietary patterns in Ossabaw pigs.

Solano-Aguilar G, Matuszek G, Matthan NR, Lichtenstein AH, Wang X, Lakshman S, Barger K, Urban JF, Molokin A, Bennett RE, Hyman BT, Lamon-Fava S

Molecular Polymorphism of tau aggregates in Pick's disease.

Liu J, Stewart TC, Hyman BT, Burghammer M, Cotte M, Makowski L

GWAS of multiple neuropathology endophenotypes identifies new risk loci and provides insights into the genetic risk of dementia.

Shade LMP, Katsumata Y, Abner EL, Aung KZ, Claas SA, Qiao Q, Heberle BA, Brandon JA, Page ML, Hohman TJ, Mukherjee S, Mayeux RP, Farrer LA, Schellenberg GD, Haines JL, Kukull WA, Nho K, Saykin AJ, Bennett DA, Schneider JA, National Alzheimer’s Coordinating Center, Alzheimer’s Disease Genetics Consortium, Ebbert MTW, Nelson PT, Fardo DW

Arc mediates intercellular tau transmission via extracellular vesicles.

Tyagi M, Chadha R, de Hoog E, Sullivan KR, Walker AC, Northrop A, Fabian B, Fuxreiter M, Hyman BT, Shepherd JD

Pathways to personalized medicine-Embracing heterogeneity for progress in clinical therapeutics research in Alzheimer's disease.

Arnold SE, Hyman BT, Betensky RA, Dodge HH

Amyloid removal and the appearance of brain volume loss.

Hyman BT

In situ seeding assay: A novel technique for direct tissue localization of bioactive tau.

Perbet R, Mate de Gerando A, Glynn C, Donahue C, Gaona A, Taddei RN, Gomez-Isla T, Lathuiliere A, Hyman BT

Aqueous extractable nonfibrillar and sarkosyl extractable fibrillar Alzheimer's disease tau seeds have distinct properties.

Mate de Gerando A, Khasnavis A, Welikovitch LA, Bhavsar H, Glynn C, Quittot N, Perbet R, Hyman BT