β-Amyloid species production and tau phosphorylation in iPSC-neurons with reference to neuropathologically characterized matched donor brains.

Oakley DH, Chung M, Abrha S, Hyman BT, Frosch MP

Neurofibrillary tangle-bearing neurons have reduced risk of cell death in mice with Alzheimer's pathology.

Zwang TJ, Sastre ED, Wolf N, Ruiz-Uribe N, Woost B, Hoglund Z, Fan Z, Bailey J, Nfor L, BuĂŠe L, Nilsson KPR, Hyman BT, Bennett RE

Astrocyte tau deposition in progressive supranuclear palsy is associated with dysregulation of MAPT transcription.

Jackson RJ, Melloni A, Fykstra DP, Serrano-Pozo A, Shinobu L, Hyman BT

Multifaceted roles of APOE in Alzheimer disease.

Jackson RJ, Hyman BT, Serrano-Pozo A

The big tau splice isoform resists Alzheimer's-related pathological changes.

Chung DC, Deng X, Yalamanchili HK, Revelli JP, Han AL, Tadros B, Richman R, Dias M, Naini FA, Boeynaems S, Hyman BT, Zoghbi HY

Interneuron diversity in the human dorsal striatum.

Garma LD, Harder L, Barba-Reyes JM, Marco Salas S, DĂ­ez-Salguero M, Nilsson M, Serrano-Pozo A, Hyman BT, MuĂąoz-Manchado AB

Machine learning of dissection photographs and surface scanning for quantitative 3D neuropathology.

Gazula H, Tregidgo HFJ, Billot B, Balbastre Y, Williams-Ramirez J, Herisse R, Deden-Binder LJ, Casamitjana A, Melief EJ, Latimer CS, Kilgore MD, Montine M, Robinson E, Blackburn E, Marshall MS, Connors TR, Oakley DH, Frosch MP, Young SI, Van Leemput K, Dalca AV, Fischl B, MacDonald CL, Keene CD, Hyman BT, Iglesias JE

Brain vasculature accumulates tau and is spatially related to tau tangle pathology in Alzheimer's disease.

Hoglund Z, Ruiz-Uribe N, Del Sastre E, Woost B, Bader E, Bailey J, Hyman BT, Zwang T, Bennett RE

Toxic effects of mutant huntingtin in axons are mediated by its proline-rich domain.

Brady ST, Mesnard-Hoaglin NA, Mays S, Priego M, Dziechciowska J, Morris S, Kang M, Tsai MY, Purks JL, Klein A, Gaona A, Melloni A, Connors T, Hyman B, Song Y, Morfini GA

SORL1 is a receptor for tau that promotes tau seeding.

Cooper JM, Lathuiliere A, Su EJ, Song Y, Torrente D, Jo Y, Weinrich N, Sales JD, Migliorini M, Sisson TH, Lawrence DA, Hyman BT, Strickland DK

The structural line between prion and "prion-like": Insights from prion protein and tau.

Glynn C, Rodriguez JA, Hyman BT

APOE2 gene therapy reduces amyloid deposition and improves markers of neuroinflammation and neurodegeneration in a mouse model of Alzheimer disease.

Jackson RJ, Keiser MS, Meltzer JC, Fykstra DP, Dierksmeier SE, Hajizadeh S, Kreuzer J, Morris R, Melloni A, Nakajima T, Tecedor L, Ranum PT, Carrell E, Chen Y, Nishtar MA, Holtzman DM, Haas W, Davidson BL, Hyman BT

Aberrant vascular architecture in the hippocampus correlates with tau burden in mild cognitive impairment and Alzheimer's disease.

Lee H, Fu JF, Gaudet K, Bryant AG, Price JC, Bennett RE, Johnson KA, Hyman BT, Hedden T, Salat DH, Yen YF, Huang SY

Characterization of monoamine oxidase-B (MAO-B) as a biomarker of reactive astrogliosis in Alzheimer's disease and related dementias.

Jaisa-Aad M, MuĂąoz-Castro C, Healey MA, Hyman BT, Serrano-Pozo A

Landscape of brain myeloid cell transcriptome along the spatiotemporal progression of Alzheimer's disease reveals distinct sequential responses to Aβ and tau.

Wachter A, Woodbury ME, Lombardo S, Abdourahman A, Wuest C, McGlame E, Pastika T, Tamm J, Romanul N, Yanamandra K, Bennett R, Lin G, Kwon T, Liao F, Klein C, Grinberg Y, Jaisa-Aad M, Li H, Frosch MP, Kummer MP, Das S, Dellovade T, Karran EH, Langlois X, Ried JS, Serrano-Pozo A, Talanian RV, Biber K, Hyman BT